Risk-reducing oophorectomy and breast cancer risk across the spectrum of familial risk

MB Terry; MB Daly; KA Phillips; X Ma; N Zeinomar; N Leoce; GS Dite; RJ MacInnis; WK Chung; JA Knight; MC Southey; RL Milne; D Goldgar; GG Giles; PC Weideman; G Glendon; R Buchsbaum; IL Andrulis; EM John; SS Buys; JL Hopper

Journal article

Risk-reducing oophorectomy and breast cancer risk across the spectrum of familial risk

MB Terry, MB Daly, KA Phillips, X Ma, N Zeinomar, N Leoce, GS Dite, RJ MacInnis, WK Chung, JA Knight, MC Southey, RL Milne, D Goldgar, GG Giles, PC Weideman, G Glendon, R Buchsbaum, IL Andrulis, EM John, SS Buys Show all

Journal of the National Cancer Institute | OXFORD UNIV PRESS INC | Published : 2019

DOI: 10.1093/jnci/djy182

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Abstract

There remains debate about whether risk-reducing salpingo-oophorectomy (RRSO), which reduces ovarian cancer risk, also reduces breast cancer risk. We examined the association between RRSO and breast cancer risk using a prospective cohort of 17917 women unaffected with breast cancer at baseline (7.2% known carriers of BRCA1 or BRCA2 mutations). During a median follow-up of 10.7 years, 1046 women were diagnosed with incident breast cancer. Modeling RRSO as a time-varying exposure, there was no association with breast cancer risk overall (hazard ratio [HR] = 1.04, 95% confidence interval [CI]=0.87 to 1.24) or by tertiles of predicted absolute risk based on family history (HR=0.68, 95% CI=0.32 t..

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University of Melbourne Researchers

Kelly Phillips Author

Gillian Dite Author

Robert MacInnis Author

Melissa Southey Author

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Funding Acknowledgements

This work was supported by the National Institute of Health USA (grant no. 1RO1CA159868). The ABCFR was supported in Australia by the National Health and Medical Research Council, the New South Wales Cancer Council, the Victorian Health Promotion Foundation, the Victorian Breast Cancer Research Consortium, Cancer Australia, and the National Breast Cancer Foundation. The six sites of the BCFR were supported by grant UM1 CA164920 from the USA National Cancer Institute at NIH.This work was supported by grants to kConFab and the kConFab Follow-Up Study from Cancer Australia (grant no. 809195), the Australian National Breast Cancer Foundation (grant no. IF 17 kConFab), the National Health and Medical Research Council (grant nos. 454508, 288704, 145684), the National Institute of Health USA (grant no. 1RO1CA159868), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia (grant numbers not applicable). KAP is a National Breast Cancer Foundation (Australia) Practitioner Fellow (grant no. PRAC-17-004).